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Language, Speech and Motor Function in MCI Due to AD and Alzheimer's Disease

NCT06508268 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 208

Last updated 2024-07-18

No results posted yet for this study

Summary

The goal of this observational cross-sectional study is to explore the characteristics of language, speech, and motor function in persons with Mild Cognitive Impairment due to Alzheimer's disease ("MCI due to AD") and persons with mild and moderate Alzheimer's disease ("AD"). This study aims to:

* Explore motor, speech, and language functions in MCI due to AD and mild and moderate AD.
* Combine the characteristics of motor, language, and speech functions to gain more insight into the association of language, speech, and motor changes during MCI due to AD and mild and moderate AD.

Researchers will compare the outcomes to an age-matched control group without cognitive impairment.

Participants will undergo:

* Two motor function tests to assess gait and hand grip strength.
* Four language and speech function tests to assess spontaneous speech and verbal fluency..

Conditions

Interventions

BEHAVIORAL

GAITRite walkway system OR 4-meter walking speed test

Gait will be assessed by the GAITRite walkway system OR the 4-meter walking speed test

BEHAVIORAL

Jamar hand dynamometer

Hand grip strength will be assessed by a Jamar hand dynamometer

BEHAVIORAL

Picture description task

Characteristics Dutch/Frisian language Language and speech will be assessed by the Cookie Theft Picture-task (a picture description task from Berube et al., 2019)

BEHAVIORAL

Autobiographical semi-structured conversation

Characteristics Dutch/Frisian language and speech will be assessed by an autobiographical semi-structured conversation

BEHAVIORAL

Verbal fluency

The mental lexicon of Dutch/Frisian language will be assessed by a two verbal fluency tests, including letter fluency and categorical fluency

Sponsors & Collaborators

  • University of Groningen

    collaborator OTHER

  • Hanze University of Applied Sciences Groningen

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-07-12
Primary Completion
2025-02-09
Completion
2025-02-09

Countries

  • Netherlands

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06508268 on ClinicalTrials.gov