Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability

Summary

This multi-center (6 sites: Helsinki, Kuopio, Oulu, Seinäjoki, Turku, Vantaa) intervention study aims to prevent cognitive impairment, dementia and disability in 60-77 year old persons at an increased dementia risk. The 2-year multi-domain life-style intervention includes nutritional guidance, exercise, cognitive training, increased social activity, and intensive monitoring and management of metabolic and vascular risk factors. The primary outcome is cognitive impairment measured by a sensitive Neuropsychological Test Battery (NTB), and Stroop and Trail Making tests to capture early cognitive impairment typical for both Alzheimer's disease and vascular dementia. We hypothesize that the multi-domain intervention will reduce cognitive impairment in the study group compared to the control group during the initial 2-year intervention period and reduce dementia incidence after the extended follow-up (until at least 300 participants have developed dementia).

Conditions

• Cognitive Impairment
• Dementia

Interventions

BEHAVIORAL

Nutritional guidance

Individual counseling sessions and group meetings will be organized.

BEHAVIORAL

Exercise

Guided muscle strength training and aerobic exercise.

BEHAVIORAL

Cognitive training

Cognitive training will be implemented through 8 group sessions lead by a psychologist and a computer-based cognitive training program available to participants via the internet.

OTHER

Reduction of vascular risk factors

Monitoring and maintenance of metabolic and vascular risk factors

Sponsors & Collaborators

• Academy of Finland

  collaborator OTHER

• University of Helsinki

  collaborator OTHER

• University of Eastern Finland

  collaborator OTHER

• University of Oulu

  collaborator OTHER

• Kuopio Research Institute of Exercise Medicine

  collaborator OTHER

• Western University, Canada

  collaborator OTHER

• Karolinska Institutet

  collaborator OTHER

• Umeå University

  collaborator OTHER

• Finnish Institute for Health and Welfare

  lead OTHER_GOV

Principal Investigators

• Miia Kivipelto, professor · Finnish Institute for Health and Welfare

• Tiina K Laatikainen, professor · Finnish Institute for Health and Welfare

• Hilkka S Soininen, professor · University of Eastern Finland

• Jaakko Tuomilehto, professor · University of Helsinki

• Timo E Strandberg, professor · University of Oulu

• Raimo Sulkava, professor · University of Eastern Finland

• Rainer Rauramaa, professor · Kuopio Research Institute of Exercise Medicine

• Antti Jula, research prof · Finnish Institute for Health and Welfare

• Markku Peltonen, research professor · Finnish Institute for Health and Welfare

• Satu Havulinna, PhD · Finnish Institute for Health and Welfare

• Jaana Lindström, Adjunct prof. · Finnish Institute for Health and Welfare

• Riitta Antikainen, professor · Oulu City Health Services

• Tiia Ngandu, MD, PhD, Adjunct professor · Finnish Institute for Health and Welfare

• Tuomo Hänninen, Adjunct prof · University of Eastern Finland

• Jenni Lehtisalo, PhD · Finnish Institute for Health and Welfare

• Alina Solomon, MD, PhD, Adjunct professor · University of Eastern Finland

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

60 Years

Max Age

77 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2009-09-30

Primary Completion

2013-12-31

Completion

2025-12-31

Countries

• Finland

Study Locations