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The Role of South Asian vs European Origins on Circulating Regenerative Cell Exhaustion

NCT05253521 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2023-02-09

No results posted yet for this study

Summary

ORIGINS-RCE is an observational, cross-sectional, two-arm study aimed at determining if an individual's ethnic origin influences the number of blood vessel-forming stem cells in the bloodstream. Circulating progenitor cells will be enumerated and the distribution patterns of these cell types will be assessed to determine if these parameters differ between individuals of South Asian origin and European origin. Specifically, this study will evaluate if differential regenerative cell exhaustion (RCE) may account, at least in part, for the differences in cardiovascular risk reported between individuals of South Asian vs European origin.

Conditions

Sponsors & Collaborators

  • Unity Health Toronto

    collaborator OTHER

  • Western University, Canada

    collaborator OTHER

  • Canadian Medical and Surgical Knowledge Translation Research Group

    lead OTHER

Principal Investigators

  • Subodh Verma, MD, PhD · University of Toronto

  • David A Hess, PhD · Western University, Canada

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-01-08
Primary Completion
2023-01-18
Completion
2023-01-18

Countries

  • Canada

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05253521 on ClinicalTrials.gov