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Identification of Genes Expressed in Atherosclerotic Plaque

NCT00353730 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 69

Last updated 2021-09-08

No results posted yet for this study

Summary

This study will identify genes and proteins in the blood of patients with atherosclerosis and in that of normal volunteers. The findings will be compared to determine the influence of these substances on the development of atherosclerosis a narrowing and hardening of blood vessel walls by deposits of fatty substances. Blood vessel blockage caused by atherosclerosis can impede blood flow and cause stroke, heart attack and poor limb circulation. The information from this study may lead to better ways to detect, prevent and treat these diseases.

Healthy volunteers and patients scheduled for carotid endarterectomy at Suburban Hospital in Bethesda, Maryland, are eligible for this study. Carotid endarterectomy is a surgical procedure in which the inner layer of the carotid artery (neck artery supplying blood to the brain) is scraped away to open the blocked vessel. Participants will undergo the following tests and procedures:

Patients

* Blood sample: Collection of about 32 cc (8 tablespoons) of blood for genetic and protein analysis
* Tissue sample: Collection of a piece of diseased blood vessel discarded from the endarterectomy procedure
* Review of records: Review of medical records for information about past illnesses, medications, tests, and so forth, if needed

Normal Volunteers

* Blood samples: Collection of about 32 cc (8 tablespoons) of blood for genetic and protein analysis
* Carotid artery ultrasound: Ultrasound imaging of the neck arteries for detection of any blockage
* Electrocardiogram: Recording of the electrical activity of the heart to detect any abnormalities in heart rhythm
* Echocardiogram: Ultrasound examination to detect possible abnormalities of the heart muscle
* Cardiac stress test: Treadmill stress test to detect possible heart vessel blockage (for subjects who have not had a cardiac stress test in the past year)
* Review of records: Review of medical records for information about past illnesses, medications, tests, and so forth, if needed

Conditions

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    lead NIH

Principal Investigators

  • Paul M Hwang, M.D. · National Heart, Lung, and Blood Institute (NHLBI)

Eligibility

Min Age
21 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2002-10-21
Primary Completion
2005-03-16
Completion
2011-01-12

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00353730 on ClinicalTrials.gov