Lipoprotein (a) and Vascular Regenerative Cell Content
NCT06626659 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40
Last updated 2025-12-29
Summary
Lp(a)-VRCE is an observational, cross sectional study looking at vessel reparative stem cell content in people with and without elevated lipoprotein (a) \[Lp(a)\]. Specifically, the type and number of these cells in peripheral blood samples will be measured in participants with Lp(a) ≥100 nmol/L and compared to participants with Lp(a) \< 100 nmol/L. Determining the presence or absence of specific cells with blood vessel repair capacity in participants with high Lp(a) will further our knowledge of potential mechanisms through which Lp(a) influences cardiovascular health.
Conditions
- Cardiovascular Diseases
- Atherosclerosis Cardiovascular Disease
- Ischemic Heart Disease
- Dyslipidemia
Sponsors & Collaborators
-
Canadian Medical and Surgical Knowledge Translation Research Group
lead OTHER
Principal Investigators
-
Subodh Verma, MD · University of Toronto
-
David A Hess, PhD · Western University, Canada
Eligibility
- Min Age
- 18 Years
- Max Age
- 80 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2024-10-05
- Primary Completion
- 2024-12-03
- Completion
- 2024-12-03
Countries
- Canada
Study Locations
More Related Trials
-
Assessment of Lipoprotein(a) and Endogenous Fibrinolysis in Atherosclerotic Cardiovascular Disease/Aortic Valve Disease
NCT06126367 ·Status: RECRUITING
-
Identification of Genes Expressed in Atherosclerotic Plaque
NCT00353730 ·Status: COMPLETED
-
Circulating Vascular Regenerative Cell Exhaustion in Individuals Without Type 2 Diabetes Who Are of South Asian or European Origins
NCT06769347 ·Status: RECRUITING
-
Epidemiology: Oxidative Stress and Early Atherosclerosis
NCT00005393 ·Status: COMPLETED
-
Association Between HDL Functions and Atherosclerotic Burden in Healthy Individuals
NCT02106013 ·Status: COMPLETED
-
Mechanisms of Disability in Peripheral Arterial Disease
NCT00046592 ·Status: COMPLETED
-
Individualized Comprehensive Atherosclerosis Risk-reduction Evaluation Program
NCT00969865 ·Status: COMPLETED
-
Molecular and Morphologic Characterization of Circulating Endothelial Cells
NCT01005485 ·Status: ACTIVE_NOT_RECRUITING
-
Role of LipoprotEin(a) in CardiovascuLar Diseases and Premature Acute Coronary Syndromes - (RELACS) Study
NCT05496790 ·Status: UNKNOWN
-
Inflammatory Genomics in Human Carotid Artery Disease
NCT00070668 ·Status: COMPLETED
-
Aging, Geriatric Syndromes and Clonal Hematopoiesis
NCT02604563 ·Status: RECRUITING
-
Effects of LDL Apheresis System on the Expression of Genes Involved in Lipoprotein Metabolism and Inflammation in Homozygotes for Familial Hypercholesterolemia
NCT02462655 ·Status: COMPLETED ·Phase: NA
-
Mechanisms of Low Levels of Apolipoprotein B
NCT00005565 ·Status: COMPLETED
-
Lipoprotein Interactions and Platelet Function in Healthy Individuals and Those With Lipid Disorders
NCT06747000 ·Status: RECRUITING
-
The Role of Glycocalyx Integrity in the Primary Prevention of Major Cardiovascular Events
NCT04646252 ·Status: RECRUITING
-
Florida Cerebrovascular Disease Biorepository and Genomics Center
NCT05491980 ·Status: ACTIVE_NOT_RECRUITING
-
Lipoprotein(a) in Patients With Cardiovascular Disease (CVD)
NCT03887520 ·Status: COMPLETED ·Phase: NA
-
RNA Cloning and Visualization in Human Atherosclerosis
NCT01928095 ·Status: COMPLETED
-
Genetic Factors in Atherosclerosis
NCT00359307 ·Status: COMPLETED
-
Diet-induced Elevations in LDL-C and Progression of Atherosclerosis
NCT05733325 ·Status: COMPLETED
-
Early Detection of Arteriosclerosis
NCT00863967 ·Status: UNKNOWN
-
Using Differences in Peripheral Blood Leukocyte Gene Expression to Determine Cardiovascular Disease Risk
NCT00613158 ·Status: COMPLETED
-
Cholesterol Self-testing in Patients Post Acute Coronary Syndrome
NCT06526013 ·Status: RECRUITING ·Phase: NA
-
High Density Lipoprotein Subspecies and Coronary Disease
NCT00005676 ·Status: COMPLETED
-
Advanced Lipoproptein Profiling and Cardiovascular Risk Stratification in Familial Hypercholesterolemia
NCT05066932 ·Status: UNKNOWN