Ischemic stroke occurs when blood flow to the brain is blocked, causing brain tissue injury from reduced oxygen delivery. It is the dominant stroke subtype and represents the majority of stroke burden in the United States.
A retrospective cohort study of 14,118 matched pairs found tirzepatide associated with lower risks of stroke and death than other GLP-1 receptor agonists in patients with atrial fibrillation and type 2 diabetes. Absolute differences were 2.1 percentage points for stroke and 6.2 for mortality at one year. Randomized trials are needed before recommendations change.
Recent studies show that resistance training lowers cardiovascular disease risk in women, muscular strength is tied to lower mortality in older women, and both weekend warrior and regular exercise patterns reduce mortality in patients with hypertension.
UKCA approval was granted for the LVOne stroke blood test, piloting with London Ambulance Service. A phase 2 trial showed LT 3001 is safe up to 24 hours post-stroke; 'leaky core' imaging links barrier disruption to worse outcomes.
Phase 3 OCEANIC-STROKE data showed asundexian plus antiplatelet therapy reduced recurrent ischemic stroke versus placebo. Major bleeding rates were similar between groups.
The phase 3 OCEANIC-STROKE trial of 12,327 patients showed asundexian, an oral Factor XIa inhibitor, reduced ischemic stroke recurrence by 26% when added to standard antiplatelet therapy, with no increase in major bleeding events.
Enlicitide decanoate demonstrated efficacy in reducing LDL cholesterol levels compared to placebo in patients with atherosclerotic cardiovascular disease history or risk, according to phase 3 CORALreef Lipids trial data.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07779668 |
AI-Driven Health Management to Prevent Ischemic Stroke in High-Risk Adults |
NOT_YET_RECRUITING | NA |
| NCT07769814 |
Photon-counting CT for Intracranial Stent Assessment |
RECRUITING | |
| NCT07766668 |
Dentate-Targeted Temporal Interference Stimulation for Post-Stroke Dysphagia |
NOT_YET_RECRUITING | NA |
| NCT07760649 |
A Study to Monitor Safety and Effectiveness of Approved J&J MedTech Devices in the Treatment of Participants With Ischemic Stroke |
NOT_YET_RECRUITING | |
| NCT07756775 |
Comparison Between Non-contrast Magnetic Resonance Angiography and Carotid Doppler in Cerebrovascular Stroke |
RECRUITING | |
| NCT07751328 |
Feasibility Assessment of the Wellumio 'Axana' 0.1T Portable MRI Device |
COMPLETED | NA |
| NCT07750860 |
Impact of Stroke Unit Care on Acute Stroke Outcomes |
NOT_YET_RECRUITING | |
| NCT07750847 |
Impact of Presenting Symptoms on Treatment Time and Outcomes in Acute Ischemic Stroke |
NOT_YET_RECRUITING | |
| NCT07748299 |
NuvOx Expanded Access |
AVAILABLE | |
| NCT07736885 |
Evaluation of Clinical Efficacy and Mechanism of Hand Jing-Well Acupoint Transcutaneous Electrical Stimulation in Improving Post-Stroke Cognitive Impairment |
RECRUITING | NA |
