Assessing an EEG Biomarker of Response to TMS for Major Depression

Summary

Veterans with treatment resistant depression (TRD) have the opportunity to receive transcranial magnetic stimulation (TMS) treatment via the VA's National TMS Clinical Pilot Program. While some see improvement with their depression, others do not. Therefore, it may be beneficial to be able to predict with biomarkers what participants may see improvement with their treatment. Electroencephalography (EEG) is a means to identify such biomarkers. Four hundred Veterans with TRD will be enrolled in this trial to determine whether neuroimaging biomarkers of repetitive transcranial magnetic stimulation (TMS) can be prospectively replicated in a large ecologically valid sample. Participants will have a total of EEG scans at baseline, every 5th treatment session, and at the end of treatment for a total of 7 EEG scans.

Conditions

• Depression

Interventions

OTHER

Transcranial Magnetic Stimulation

Transcranial Magnetic Stimulation is delivered as part of routine care and is not managed by this observational study.

Sponsors & Collaborators

• VA Palo Alto Health Care System

  collaborator FED

• Minneapolis Veterans Affairs Medical Center

  collaborator FED

• Providence VA Medical Center

  collaborator FED

• James A. Haley Veterans Administration Hospital

  collaborator FED

• White River Junction Veterans Affairs Medical Center

  collaborator FED

• Emory University

  collaborator OTHER

• University of California, Los Angeles

  collaborator OTHER

• Edward Hines Jr. VA Hospital

  collaborator FED

• VA Greater Los Angeles Healthcare System

  collaborator FED

• VA Pittsburgh Healthcare System

  collaborator FED

• San Diego Veterans Healthcare System

  collaborator FED

• Michael E. DeBakey VA Medical Center

  collaborator FED

• VA Office of Research and Development

  lead FED

Principal Investigators

• Paul Holtzheimer, MD · White River Junction VA Medical Center, White River Junction, VT

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-08-19

Primary Completion

2025-09-30

Completion

2026-09-30

Countries

• United States

Study Locations