Neural Circuit Biomarkers of Transcranial Magnetic Stimulation Study

Summary

This study is currently recruiting Veterans only. The objective of this observational study is to test whether neuroimaging biomarkers of repetitive transcranial magnetic stimulation (TMS) can be prospectively replicated in a large ecologically valid sample. We focus on cognitive network connectivity as a predictive biomarker of the clinical effect of TMS, and as a response biomarker of change with TMS. We address this objective through a pragmatic approach in which we recruit patients undergoing routine clinical care and program evaluation in a Veterans Administration multi-site clinical TMS program.

Conditions

• Depression

Interventions

OTHER

transcranial magnetic stimulation

transcranial magnetic stimulation is delivered as part of routine care and is not managed by this observational study

Sponsors & Collaborators

• VA Palo Alto Health Care System

  collaborator FED

• Florida State University

  collaborator OTHER

• University of South Florida

  collaborator OTHER

• Medical University of South Carolina

  collaborator OTHER

• University of Minnesota

  collaborator OTHER

• Minneapolis Veterans Affairs Medical Center

  collaborator FED

• Brown University

  collaborator OTHER

• Providence VA Medical Center

  collaborator FED

• Dartmouth College

  collaborator OTHER

• Dartmouth-Hitchcock Medical Center

  collaborator OTHER

• White River Junction VA Medical Center

  collaborator UNKNOWN

• Stanford University

  lead OTHER

Principal Investigators

• Leanne Williams, PhD · Stanford University

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-11-02

Primary Completion

2026-05-31

Completion

2026-05-31

Countries

• United States

Study Locations