Depression is a common mental disorder characterized by persistent low mood or loss of interest and pleasure over extended periods. It can impair social, occupational, and daily functioning, and in severe cases can lead to suicide. Effective treatments exist for mild, moderate, and severe depression.
A genetic framework using Mendelian randomization identified and prioritized drug targets for major depression from over 525,000 cases. The study found drugs targeting genetically supported proteins are 2.6 times more likely to succeed and prioritized 54 repurposing opportunities using existing medications for other conditions.
Vaccine denial and weakened public health measures risk increasing chronic illness, as historical data shows post-infectious conditions follow major outbreaks. Long COVID affects 10-20% of those infected, while historical pandemics led to conditions like encephalitis lethargica with near 50% mortality.
Advances in precision mental health research include TMS findings published in Nature Molecular Psychiatry showing targeted brain stimulation can address specific depression and anxiety symptoms, the launch of the three-year GlobalMinds NHS genomic study analyzing 49,000 DNA samples, and the new $1 million Wellcome Prize for Mental Health Science.
Acromegaly patients face persistent symptoms including fatigue, joint pain, headaches, and brain fog despite biochemical control. Treatment burden and financial barriers remain significant, particularly in sub-Saharan Africa where diagnostic tools and therapies are often inaccessible.
A review of more than 200 studies linked up to a third of dementia cases to diseases outside the brain. Trials and broader evidence also support multi-domain prevention strategies.
A large analysis of 131,821 health professionals found that two to three cups of caffeinated coffee a day were linked to a 19 percent lower dementia risk. One daily cup of caffeinated tea was linked to a 14 percent lower risk.
AbbVie raised 2026 revenue and EPS guidance after first-quarter results beat estimates, with Skyrizi and Rinvoq driving growth. Humira erosion continued as neuroscience, oncology and pipeline assets supported the outlook.
A 12-week supervised remote exercise program for patients with metastatic renal cell carcinoma undergoing immunotherapy showed significant improvements in health-related quality of life, fatigue, and symptom burden in a case series of 19 patients.
Research and survey data point to lifelong learning, midlife stimulating activities and treatment of health risks as factors linked to better brain health and lower dementia risk.
A longitudinal study of 460,000 teenagers found adolescent cannabis use was linked to higher risks of later bipolar, psychotic, anxiety and depression diagnoses. Separate research and expert guidance say THC effects, especially long term, still need more study.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07610655 |
Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression |
RECRUITING | NA |
| NCT07610369 |
The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease |
NOT_YET_RECRUITING | PHASE2 |
| NCT07604389 |
AR Health Education Video for Postoperative Breast Cancer Patients |
RECRUITING | NA |
| NCT07599124 |
Effectiveness of Light Therapy Across Seasons |
COMPLETED | |
| NCT07592117 |
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Tavua, Fiji |
NOT_YET_RECRUITING | NA |
| NCT07591363 |
Improving Mental Health Through Emotional Intelligence Enhancement |
RECRUITING | NA |
| NCT07582666 |
Identifying and Mobilizing Personal Resources to Improve Well-Being in Cancer Participants Using the CAERES Protocol |
COMPLETED | NA |
| NCT07582120 |
Psilocybin-Assisted Therapy as a Treatment for Depression |
NOT_YET_RECRUITING | PHASE2 |
| NCT07579481 |
Vortioxetine in Depression and Concomitant Migraine |
RECRUITING | |
| NCT07577947 |
Health And Response: Digital Markers for Outcomes in Perinatal Depression Treatment Study |
NOT_YET_RECRUITING | NA |
