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Repetitive Transcranial Magnetic Stimulation and Acceptance and Commitment Therapy

NCT05427201 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 31

Last updated 2025-06-08

No results posted yet for this study

Summary

Veterans with comorbid chronic pain and depression are highly prevalent, have poor functional status and low quality of life, are at increased risk of suicide and lack access to effective treatments. To address this problem, the proposed research will examine the feasibility of a novel approach that integrates repetitive Transcranial Magnetic Stimulation and Acceptance and Commitment Therapy with the overall goal of maximizing functional improvement in Veterans with chronic pain and depression. This is an important first-step in preparation for a future randomized efficacy trial. The investigators will also include two cognitive control tasks with concurrent electroencephalography to explore as a potential objective indicator of treatment response. This application addresses a critical need within the Veterans Health Administration and is closely aligned with the focus area of developing suicide prevention treatments that influence participation in life roles.

Conditions

Interventions

DEVICE

Repetitive Transcranial Magnetic Stimulation

rTMS is a non-invasive brain stimulation technique designed to alter network function

BEHAVIORAL

Acceptance and Commitment Therapy

ACT is a mindfulness-based cognitive behavioral intervention that has demonstrated efficacy for chronic pain.

Sponsors & Collaborators

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Matthew Herbert, PhD · VA San Diego Healthcare System, San Diego, CA

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-05-22
Primary Completion
2025-05-30
Completion
2025-05-30
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05427201 on ClinicalTrials.gov