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Cortical Excitability and Inhibition in MDD

NCT01718730 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 23

Last updated 2019-10-22

No results posted yet for this study

Summary

The purpose of this study is to learn if measures of brain activity are different in children and adolescents with depression who are in different stages of treatment. This is important because it may identify a biological marker for depression that could one day be used to identify depressed children who would benefit from certain treatments (medications for example), or to monitor how well treatments are working. Brain activity measures(known as cortical excitability and inhibition) will be collected by Transcranial Magnetic Stimulation (TMS). TMS is a noninvasive (no surgery or implants) brain stimulation technology which can make parts of the brain work without putting any wires or chemicals into the body. Measurements will take place over one 3-hour visit. This study does not provide any form of treatment.

\*There is an optional portion of the study that uses a brain scan to gather measures of brain structure and brain chemicals. The brain scan is called magnetic resonance and spectroscopy (MRI/MRS). MRI/MRS uses magnetic fields to study the structure of the brain and brain chemicals. The PI will determine eligibility for the MRI/MRS portion of the study.

Conditions

  • Major Depressive Disorder, Recurrent, Mild
  • Depressive Disorder, Major

Interventions

DEVICE

Transcranial Magnetic Stimulation (TMS)

Single and paired-pulse TMS applied to the motor cortex will collect measures of cortical excitability and inhibition.

DEVICE

Magnetic Resonance Spectroscopy and Imaging

MRS/MRI Scans will examine glutamate concentrations in the motor cortex and anterior cingulate cortex.

Sponsors & Collaborators

  • Neuronetics

    collaborator OTHER

  • Mayo Clinic

    lead OTHER

Principal Investigators

  • Paul E Croarkin, D.O. · Mayo Clinic

Eligibility

Min Age
13 Years
Max Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-10-31
Primary Completion
2019-08-31
Completion
2019-08-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01718730 on ClinicalTrials.gov