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Biomarker-guided rTMS for Treatment Resistant Depression

NCT04041479 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 348

Last updated 2026-02-25

No results posted yet for this study

Summary

Repetitive transcranial magnetic stimulation (rTMS) is a treatment for depression. The investigators are continuing to learn how to optimize outcomes from rTMS treatment. The purpose of this research project is to use brain network connectivity patterns as measured by resting state functional magnetic resonance imaging (fMRI) to confirm a way to optimize the use of rTMS to treat depression. In addition, the study aims to gain a better understanding of how rTMS influences brain networks.

Conditions

Interventions

DEVICE

Repetitive Transcranial Magnetic Stimulation

iTBS rTMS targeting the DMPFC or left DLPFC

DEVICE

Repetitive Transcranial Magnetic Stimulation

iTBS rTMS targeting the left DLPFC

Sponsors & Collaborators

  • National Institute of Mental Health (NIMH)

    collaborator NIH

  • Stanford University

    collaborator OTHER

  • Weill Medical College of Cornell University

    lead OTHER

Principal Investigators

  • Conor Liston, MD, PhD · Weill Medical College of Cornell University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
22 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-09-17
Primary Completion
2027-04-30
Completion
2027-08-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04041479 on ClinicalTrials.gov