Function of Circulating Exosomes in Sepsis-induced Immunosuppression
NCT04979767 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 80
Last updated 2021-07-28
Summary
This is a single-center prospective bio-specimen analysis and observational study aiming to define immune pathways disrupted in bacterial sepsis and to identify clinically useful biomarkers of immune status.
Conditions
- Sepsis
- Septic Shock
- Sepsis Syndrome
- Sepsis Bacterial
- Sepsis, Severe
- Sepsis Bacteremia
Sponsors & Collaborators
-
University of Kansas
collaborator OTHER -
University of Kansas Medical Center
lead OTHER
Principal Investigators
-
Nicholas S Britt, PharmD · University of Kansas Medical Center
Eligibility
- Min Age
- 50 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2021-04-15
- Primary Completion
- 2021-10-31
- Completion
- 2022-06-30
Countries
- United States
Study Locations
More Related Trials
-
Immunomodulatory Properties of Ketamine in Sepsis
NCT01089361 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Dynamics of Organ Damage and Immune Exhaustion During Sepsis
NCT06817408 ·Status: RECRUITING
-
Biomarkers in Exhaled Breath Condensates of Septic Patients to Predict Development of Multi-organ Dysfunction Syndrome
NCT01503684 ·Status: UNKNOWN
-
Myeloid-derived Suppressor Cells in Sepsis
NCT03540797 ·Status: UNKNOWN
-
Septic Shock-induced Immunosuppression
NCT04067674 ·Status: RECRUITING
-
Comparative Study of the Protein C Pathway in Septic and Non Septic Patients With Organ Failure
NCT00361725 ·Status: TERMINATED
-
Effects of Endotoxin Absorption and Cytokine Removal Hemofilter on Severe Septic Shock
NCT03974386 ·Status: COMPLETED ·Phase: NA
-
Study and Role of Inflammasome in Platelet Activation During Bacterial And/or Viral Sepsis
NCT06657781 ·Status: RECRUITING
-
Does GM-CSF Restore Neutrophil Phagocytosis in Critical Illness?
NCT01653665 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Genomics in Infection and Sepsis to Predict Organ Dysfunction and Outcomes in Sepsis
NCT04199962 ·Status: UNKNOWN
-
Immune Homeostasis in Sepsis and Septic Shock
NCT04448951 ·Status: RECRUITING
-
The Effects of Immunostimulation With GM-CSF or IFN-y on Immunoparalysis Following Human Endotoxemia
NCT01374711 ·Status: COMPLETED ·Phase: NA
-
Effect of Enteral Genistein Supplementation in Sepsis
NCT02796794 ·Status: UNKNOWN ·Phase: PHASE4
-
Following of Myeloid-derived Suppressor Cells (MDSC) in Severe Sepsis: What Relationship With Systemic Inflammatory Syndrome?
NCT02903082 ·Status: TERMINATED
-
Immune Profile of Patients With Sepsis
NCT04163705 ·Status: UNKNOWN
-
Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis
NCT02539147 ·Status: COMPLETED
-
Cytokine Response in Septic Shock
NCT01770457 ·Status: UNKNOWN
-
Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock
NCT05969275 ·Status: RECRUITING ·Phase: PHASE2
-
Cellular Immunotherapy for Septic Shock: A Phase I Trial
NCT02421484 ·Status: COMPLETED ·Phase: PHASE1
-
Role of Transposable Elements in Septic Immune Aging
NCT06809868 ·Status: RECRUITING
-
Safety and Efficacy of Extracorporeal Cytokine Hemoadsorption in Septic Shock in Critically Ill Cirrhotics
NCT03866083 ·Status: UNKNOWN ·Phase: NA
-
TRIM25 in Septic Patients
NCT07320638 ·Status: ENROLLING_BY_INVITATION
-
Defining Circulating Micro-RNA Biomarkers for the Early Diagnosis and Prognosis of Sepsis
NCT02544490 ·Status: COMPLETED
-
Cellular Immunotherapy for Septic Shock
NCT03369275 ·Status: UNKNOWN ·Phase: PHASE2
-
Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis
NCT00185783 ·Status: COMPLETED