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Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis

NCT02539147 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 6

Last updated 2017-02-23

No results posted yet for this study

Summary

Activation of caspase-4 and human caspase-5 (orthologs of caspase-11 in mice) in innate immune cells.

Conditions

  • Severe Sepsis

Interventions

BIOLOGICAL

blood samples

Isolation and stimulation of monocytes, preparation of cell lysates, measurement of cytokine production, Western blot

Sponsors & Collaborators

  • Institut Pasteur

    collaborator INDUSTRY

  • Agency for Science, Technology and Research

    collaborator OTHER

  • Fondation Hôpital Saint-Joseph

    lead OTHER

Principal Investigators

  • Benoit Misset, Professor · Fondation Hôpital Saint-Joseph

  • Jean Marc Cavaillon, Professor · Unité Cytokines et Inflammation, Institut Pasteur, Paris

  • Alessandra Mortellaro · Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, #04-06 Immunos, Singapore

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-09-30
Primary Completion
2014-12-31
Completion
2014-12-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02539147 on ClinicalTrials.gov