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Defining Circulating Micro-RNA Biomarkers for the Early Diagnosis and Prognosis of Sepsis

NCT02544490 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 450

Last updated 2019-03-13

No results posted yet for this study

Summary

The objectives are to:

1. derive and validate a panel of miRNAs that are consistently differentially expressed in the plasma of patients with and without sepsis
2. investigate the prognostic and predictive values of the panel of miRNAs to guide treatment
3. investigate the roles of these differentially-expressed circulating miRNAs in immune modulation during sepsis

The methodology involves sampling of blood from controls and subjects in the sepsis continuum at their earliest presentation in the emergency department longitudinally to hospitalization. The investigators will develop panels of miRNAs that are specific to early and late stages of sepsis, and correlate clinical, biochemical and microbiological outcomes with these miRNAs.

Conditions

Sponsors & Collaborators

  • National University of Singapore

    collaborator OTHER

  • MiRXES Pte Ltd

    collaborator INDUSTRY

  • A*Star

    collaborator OTHER

  • National University Hospital, Singapore

    lead OTHER

Principal Investigators

  • Win Sen Kuan, MBBS · National University Hospital, Singapore

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-09-30
Primary Completion
2018-12-31
Completion
2018-12-31

Countries

  • Singapore

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02544490 on ClinicalTrials.gov