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Role of Transposable Elements in Septic Immune Aging

NCT06809868 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 116

Last updated 2026-01-30

No results posted yet for this study

Summary

The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is:

1. Do transposable elements prematurely age the immune systems of patients with sepsis?
2. Do transposable elements correlate with increased mortality in patients with sepsis in the ICU?
3. Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU?

Participants will have blood drawn from them but will not be subjected to additional interventions.

Conditions

  • Sepsis
  • Sepsis and Septic Shock
  • Sepsis With Multiple Organ Dysfunction (MOD)
  • Sepsis With Acute Organ Dysfunction
  • Sepsis, Severe
  • Sepsis at Intensive Care Unit
  • Sepsis, Severe Sepsis and Septic Shock
  • Sepsis, Septic Shock

Interventions

GENETIC

RNA and DNA Sequencing

DNA and RNA sequencing will be conducted on both control participants and patients with sepsis who are admitted to the ICU.

Sponsors & Collaborators

Principal Investigators

  • Alexendar R Perez, M.D., Ph.D · University of California, San Francisco

  • Judith Hellman, M.D. · University of California, San Francisco

  • Matthieu Legrand, M.D., Ph.D · University of California, San Francisco

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-02-14
Primary Completion
2028-02-14
Completion
2028-08-14

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06809868 on ClinicalTrials.gov