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Association of Hb F Level With Clinical Severity of Beta Thalassemia

NCT04917978 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1200

Last updated 2021-06-11

No results posted yet for this study

Summary

The production of Hb F after birth is an important factor in modifying the clinical severity of beta thalassemia because an increased gamma-globin level will bind the additional a-globin and form Hb F. The objective of this project is to evaluate the association of Hb F level with phenotypic diversity of patients with beta thalassemia.

Conditions

  • Beta Thalassemia

Interventions

DIAGNOSTIC_TEST

Hematological Phenotype Analysis

Hematological parameters were determined with an automated hematology analyzer (Sysmex, Japan), and hemoglobin analysis was performed with either high-performance liquid chromatography (Bio- Rad, USA) or capillary electrophoresis (Sebia, France and Helena, USA).

Sponsors & Collaborators

  • ZhuHai Hospital

    collaborator OTHER

  • Shenzhen Children's Hospital

    collaborator OTHER_GOV

  • Shenzhen Second People's Hospital

    collaborator OTHER

  • Jiangmen Maternity and Child Health Care Hospital

    collaborator UNKNOWN

  • Yongzhou Maternity and Child Health Hospital

    collaborator UNKNOWN

  • Nanfang Hospital, Southern Medical University

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-12-01
Primary Completion
2024-12-30
Completion
2025-12-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04917978 on ClinicalTrials.gov