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Screening of Coexistence Between Sickle Cell Anaemia and G6PD Deficiency

NCT06615024 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2024-09-26

No results posted yet for this study

Summary

G6PD deficiency may have a subtle effect on the severity of hemolysis and also worsen the degree of anaemia in SCD when the two disorders coexist. Therefore, selective decision should be taken in patients in whom the two conditions coexist in the choice of drug and in the treatment of infections.The prevalence of the G-6-PD deficiency is high in SCD patients, but does not differ from that observed among non-SCD subjects .However, the G-6-PD deficiency appears to worsen the clinical features of SCD, there were more hospitalizations, major vaso-occlusive crises among G-6-PD deficient sickle cell patients.

Conditions

  • Sickle Cell Disease and G6PD Deficiency

Interventions

DIAGNOSTIC_TEST

G6pd enzyme sickling test

Measuring the enzyme level of G6PD and presence of Hbs

DIAGNOSTIC_TEST

G6PD enzyme and sickling test

Measuring enzyme level of G6PD and level of HbS

DIAGNOSTIC_TEST

G6PD enzyme and HPLC

Measuring G6PD enzyme level in neonates and measuring level of HbS

Sponsors & Collaborators

  • Fatma Hussein Mahmoud

    lead OTHER

Eligibility

Min Age
1 Day
Max Age
28 Days
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-31
Primary Completion
2026-01-31
Completion
2026-02-28

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06615024 on ClinicalTrials.gov