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A Retrospective Study on the Effect of HBA or HBB Genetic Defects on Early Embryonic Development

NCT03687567 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 737

Last updated 2022-01-11

No results posted yet for this study

Summary

Thalassemia is an anemia or pathological state caused by compounding absently or inadequately of one or more globin chains of hemoglobin due to the defects of the globin gene,and the carrying rate is high in southern China. Although there are many studies of Thalassemia, the relationship between the globin gene defects and the early embryo development has not been reported.

This study intends to carry out a retrospective analysis on the embryonic development of the patients with thalassemia assisted by PGD from January 1, 2011 to now in our hospital, to explore whether the HBA or HBB gene defects have a certain influence on the early embryo development, so as to accumulate certain data for reproductive health research.

Conditions

  • Thalassemia,Embryonic Development,Reproductive Sterility and Infertility

Interventions

PROCEDURE

Preimplantation genetic diagnosis

Sponsors & Collaborators

  • Reproductive & Genetic Hospital of CITIC-Xiangya

    lead OTHER

Principal Investigators

  • Liang Hu, MD,PHD · Reproductive & Genetic Hospital of CITIC-Xiangya

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-09-01
Primary Completion
2018-07-31
Completion
2020-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03687567 on ClinicalTrials.gov