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NAVA vs PSV Ventilation During Weaning From Mechanical Ventilation in Children After Liver Transplantation

NCT04792788 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2021-10-22

No results posted yet for this study

Summary

Liver transplantation is the treatment of choice for acute and chronic end-stage liver disease. Neurally Adjusted Ventilator Assist (NAVA) may be a feasible solution to guide the liberation from mechanical ventilation reducing asynchronies between patient and ventilator, and optimizing ventilator cycling. Cardiovascular and respiratory effects during NAVA ventilation are very limited after major abdominal surgery. The purpose of this application is to explore the efficacy of NAVA to reduce the asynchronies between the ventilator and pediatric patient admitted in Pediatric Intensive Care Unit (PICU) after major abdominal surgery, and the relationship between an optimal level of NAVA and cardiac and pulmonary function.

Conditions

  • Pediatric Liver Transplantation
  • Weaning From Mechanical Ventilation

Interventions

PROCEDURE

Weaning from mechanical ventilation

Cross over study: 3 periods of 40 minutes in ventilation mode (NAVA or PSV); to register ventilator traces and cardiopulmonary parameters during the last 10 minutes of each period.

Sponsors & Collaborators

  • Catholic University of the Sacred Heart

    collaborator OTHER

  • Bambino Gesù Hospital and Research Institute

    lead OTHER

Principal Investigators

  • Fabrizio Chiusolo, MD · Bambino Gesù Hospital and Research Institute

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
1 Month
Max Age
10 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-09-01
Primary Completion
2021-11-01
Completion
2022-01-30

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04792788 on ClinicalTrials.gov