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Neurally Adjusted Ventilatory Assist (NAVA) Study in Adults With Acute Respiratory Failure

NCT01730794 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 306

Last updated 2020-01-27

No results posted yet for this study

Summary

The purpose of this study is to compare a specific mode of artificial ventilation (help from a breathing machine) with other modes. This specific mode is called Neurally Adjusted Ventilatory Assist (NAVA) and is different from other modes as it uses direct signals from the diaphragm (breathing muscle) to help patients breathe. The investigators believe that using these signals, NAVA can determine the exact timing for patients' spontaneous breathing effort and delivers the artificial breath at the same time (in synchrony) with their own breath. Other modes (breathing methods) may cause asynchrony between the patient and the ventilator while delivering artificial breaths because of the way they operate. Asyncrony between patient and ventilator is a risk factor for increasing the length of artificial ventilation and number of related complications. The investigators would like to find out if NAVA performs better in establishing synchrony between patient and ventilator and as a result decreasing time for artificial ventilation and increasing better outcomes.

Conditions

  • Acute Respiratory Failure

Interventions

OTHER

NAVA ventilation

Neurally adjusted ventilatory assist

OTHER

Conventional Lung Protective Ventilation

conventional protective mechanical ventilation

Sponsors & Collaborators

  • Dr. Negrin University Hospital

    collaborator OTHER

  • Massachusetts General Hospital

    lead OTHER

Principal Investigators

  • Robert M Kacmarek, PhD · Massachusetts General Hospital

  • Jesus Villar, MD, PhD · Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-03-28
Primary Completion
2020-01-22
Completion
2020-01-22

Countries

  • China
  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01730794 on ClinicalTrials.gov