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Physiological Response in Lung Transplant Recipients Undergoing Neurally Adjusted Ventilatory Assist

NCT03367221 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2017-12-08

No results posted yet for this study

Summary

Primary Graft Dysfunction (PGD) respresents the leading cause of mortality in early post-operative period of Lung Tranplantation (LTx). Protective ventilatory strategy could potentially reduce the risk of PGD in these patients. Neurally Adjusted Ventilatory Assist (NAVA) is an assisted ventilation mode that could allow to adopt this strategy. Aim of the study is to assess the feasibility of NAVA in the early post-LTx phase and to describe the breathing pattern and the physiological relationship between neural respiratory drive and different levels of ventilatory assist, in the absence of pulmonary vagal afferent feedback.

Conditions

  • Work of Breathing
  • Lung Transplant; Complications
  • Neurally Adjusted Ventilatory Assist
  • Ventilator-Induced Lung Injury

Interventions

DEVICE

NAVA ventilation

Assisted Ventilation Mode, synchronized, through EAdi catheter, with patient's inspiratory effort and proportional to respiratory drive

Sponsors & Collaborators

  • University of Lausanne Hospitals

    collaborator OTHER

  • Policlinico Hospital

    lead OTHER

Principal Investigators

  • Chiara Abbruzzese, MD · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

  • Luigi Castagna, MD · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

  • Nicola Bottino, MD · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

  • Alberto Zanella, MD · University of Milan

  • Nadia Corcione, MD · Fondazione IRCCS Ca' Granda

  • Antonio Pesenti, Prof · University of Milan

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-11-23
Primary Completion
2019-11-30
Completion
2019-11-30

Countries

  • Italy
  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03367221 on ClinicalTrials.gov