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Microbiota and Allergy

NCT04750980 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2021-07-27

No results posted yet for this study

Summary

Food allergy derives from a dysregulation of oral tolerance mechanisms. Studies suggest a crucial role for gut microbiota in oral tolerance development. An altered composition of gut microbiota results in an unbalanced local and systemic immune response to food allergens. There are qualitative and quantitative differences in gut microbiota composition in children with food allergy. Preliminary results of MATFA study demonstrated gut microbiota in allergic children.These findings support the pivotal role of the gut microbiota in the pathogenesis of allergic diseases and may open new strategies in the development of innovative preventive and therapeutic approaches.

Conditions

  • Allergy

Interventions

OTHER

food allergy

food allergy

OTHER

respiratory allergy

respiratory allergy

OTHER

healthy controls

healthy controls

Sponsors & Collaborators

  • Federico II University

    lead OTHER

Eligibility

Min Age
48 Months
Max Age
84 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-06-01
Primary Completion
2021-01-30
Completion
2021-01-30

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04750980 on ClinicalTrials.gov