MedTrace Logo

Endogenous Energy Production in Critically Ill Patients

NCT07059988 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2025-07-11

No results posted yet for this study

Summary

The aim of this study is to investigate when critically ill patients transition from a non-suppressible catabolism to a normal response to feeding.

Endogenous production of glucose, fat and protein will be studied on a minimum of two occasions in mechanically ventilated ICU patients, in a fasted state and during parenteral nutrition. Substrate kinetics are estimated by a tracer dilution method using infusions of isotopically labeled glucose, glycerol and phenylalanine. Blood sampling for metabolomics analysis will be performed to elucidate potential biomarkers indicating an anabolic response to nutrition.

Conditions

  • Critical Illness
  • Metabolism and Nutrition Disorder

Interventions

OTHER

Stable isotope tracers

Deuterium-labelled non-radioactive stable isotopes of glucose, phenylalanine and glycerol.

DIETARY_SUPPLEMENT

Parenteral nutrition

Parenteral nutrition infused a rate corresponding to 100% of measured energy expenditure, started after blood sampling during a baseline fasting period.

Sponsors & Collaborators

  • Karolinska University Hospital

    lead OTHER

Principal Investigators

  • Olav Rooyackers, PhD · Karolinska University Hospital/Karolinska Institute

  • Martin Sundström Rehal, MD PhD · Karolinska University Hospital/Karolinska Institute

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-07-31
Primary Completion
2026-12-31
Completion
2027-05-31

Countries

  • Sweden

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07059988 on ClinicalTrials.gov