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The Effect of Exercise on Serum Levels of Collagen and Proteoglycan in Patients With Knee Osteoarthritis

NCT04542668 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2021-06-08

No results posted yet for this study

Summary

The aim of EFEX-OA-02 is to explore how running, cycling, exercise simulation and resting acutely influence collagen and proteoglycan homeostasis in OA, as reflected by changes in collagen and proteoglycan levels in urine and serum.

Conditions

  • Osteoarthritis, Knee

Interventions

OTHER

Cycling then running

Ergometer cycling Treadmill running

OTHER

Running then cycling

Treadmill running Ergometer cycling

OTHER

Inotropy

Adrenaline induced inotropy

OTHER

Resting

Subjects must be minimally physically active

Sponsors & Collaborators

  • University of Copenhagen

    collaborator OTHER

  • NBCD A/S

    collaborator INDUSTRY

  • Nordic Bioscience A/S

    lead INDUSTRY

Principal Investigators

  • Niels Secher, MD, DMSci · University of Copenhagen

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
40 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-10-08
Primary Completion
2021-06-07
Completion
2021-06-07

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04542668 on ClinicalTrials.gov