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Influence of Weight Loss or Exercise on Cartilage in Obese Knee Osteoarthritis Patients

NCT00655941 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 192

Last updated 2012-01-06

No results posted yet for this study

Summary

Obesity and osteoarthritis (OA) co-exist in an increasing part of the population.

The two diseases intertwine in several ways. The evolution in the population shows a tendency towards deterioration of both by increasing general age and weight. The two diseases share pathogenetic features and the development of one disease increases the risk of the other and may be the onset of a vicious circle.

There is a link between treatments of these two diseases as well. There is now solid (gold) evidence that by treating effectively the obesity of patients with co-occurring OA, the functional status is dramatically ameliorated; the short-term results are equal to that of a joint replacement. The long-term efficacy of a weight loss remains to be shown. OA is definitely one of many diseases in which obesity must be taken seriously into account when planning a correct treatment of patients. This trial has two phases, the first (16 weeks) consisting of a dietary intervention with low-energy diet and the second (52 weeks) a randomized, three group (each n\>50 patients) controlled study of maintenance of weight loss by either continuing dietary instruction, exercise, or a control group. The hypothesis is that maintenance of an initially induced weight loss is dependent on attention rather than any specific therapy.

Conditions

Interventions

BEHAVIORAL

Dietary instruction

Weekly instruction by dieticians

OTHER

Exercise

Supervised exercise in groups

Sponsors & Collaborators

  • Velux Fonden

    collaborator OTHER

  • Oak Foundation

    collaborator OTHER

  • The Danish Rheumatism Association

    collaborator OTHER

  • Cambridge Weight Plan Limited

    collaborator INDUSTRY

  • Henning Bliddal

    lead OTHER

Principal Investigators

  • Henning Bliddal, Professor,MD · The Parker Institute, Frederiksberg Hospital, Denmark

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-04-30
Primary Completion
2010-01-31
Completion
2010-01-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00655941 on ClinicalTrials.gov