Clinical and Functional Outcomes of Critically Ill Patients With COVID-19

Summary

People affected by Severe Acute Respiratory Syndrome (SARS) by COVID-19 virus my require a long lasting invasive mechanical ventilation life support. To prevent damages to the lungs a number of protective lung ventilation measures are taken, one of them encounters the positive end expiratory pressure (PEEP) titration. Up to date, it is unclear the best method to titrate PEEP considering this unconventional syndrome compared to other etiologies. In addition to the long lasting advanced life support and bedridden condition, other factors may affect respiratory and peripheral muscle function of these patients. Therefore, the investigators intend to follow up these patients randomized to one of the three-arm experimental PEEP titration and after ICU discharge their status on clinical, laboratory and physical functions assessments.

Conditions

• Acute Respiratory Distress Syndrome (ARDS)

Interventions

OTHER

ARDSNet table

The setting of the lowest PEEP level and FiO2 match stated by the table to achieve a goal oxygenation.

OTHER

Driving Pressure

The setting of the lowest PEEP level by the lowest correspondent driving pressure, which is defined by the difference of plateau pressure, after a modified alveolar recruitment maneuver.

OTHER

Electrical Impedance Tomography

The setting of the PEEP level above the intersection of the curves representing relative alveolar overdistention and collapse, after a modified alveolar recruitment maneuver.

Sponsors & Collaborators

• Universidade Federal de Pernambuco

  collaborator OTHER

• Coordination for the Improvement of Higher Education Personnel

  collaborator OTHER

• Conselho Nacional de Desenvolvimento Científico e Tecnológico

  collaborator OTHER_GOV

• Fundação de Amparo à Ciência e Tecnologia de Pernambuco

  collaborator OTHER

• University of Pernambuco

  lead OTHER

Principal Investigators

• Shirley Lima Campos, PhD · Universidade Federal de Pernambuco

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-10-21

Primary Completion

2021-07-11

Completion

2022-12-30

Countries

• Brazil

Study Locations