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Cambridge 7 Tesla Cerebral Small Vessel Disease Study

NCT04330222 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 210

Last updated 2022-09-21

No results posted yet for this study

Summary

CamSVD is jointly sponsored by the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust.

We aim to explore and understand the underlying arterial pathology in Cerebral Small Vessel Disease (SVD) using ultra-high-field 7 Tesla MRI. We will optimise 7T Time-of-Flight MR angiography, blood suppressed MR sequence and phase-contrast (PC) MR angiography for visualization of perforating lenticulostriate arteries. This optimised sequences will be used to determine the range of arterial pathologies seen in individuals presenting with lacunar strokes. The pathologies of the perforating lenticulostriate arteries will be correlated with conventional clinical risk factors, cognition and radiological markers of SVD.

Conditions

  • Cerebral Small Vessel Diseases
  • Cerebral Small Vessel Ischemic Disease
  • Lacunar Stroke

Interventions

DIAGNOSTIC_TEST

7 Tesla Magnetic Resonance Imaging

Diagnostic Imaging

OTHER

Brief Memory and Executive Test

Cognitive Assessment

Sponsors & Collaborators

  • Cambridge University Hospitals NHS Foundation Trust

    collaborator OTHER

  • Wolfson Brain Imaging Centre

    collaborator UNKNOWN

  • University of Cambridge

    lead OTHER

Principal Investigators

  • Hugh Markus, FMedSci · University of Cambridge Department of Clinical Neurosciences

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-03-09
Primary Completion
2024-01-12
Completion
2024-01-12

Countries

  • United Kingdom

Study Locations

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Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04330222 on ClinicalTrials.gov