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Retinal, Cerebral and Vascular Precursor Markers of Cerebral Small Vessel Disease.

NCT05305144 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 206

Last updated 2023-10-06

No results posted yet for this study

Summary

Cognitive impairment and dementia are primarily due to a combination of vascular brain injury and neurodegenerative lesions. The vascular component is now recognized as a major contributor to the pathophysiology of dementia, with small vessel disease (SVD) being its most frequent substrate. This study aims to collect retinal microvascular markers as well as various parameters related to blood pressure and arterial stiffness, in a young adult population. The main objective is to explore the association between these parameters and structural changes on brain MRI. Results will allow to determine the most relevant biomarkers associated with very early brain imaging markers of SVD.

Conditions

  • Cerebral Small Vessel Diseases

Interventions

PROCEDURE

Vascular and ophthalmological examinations

Part. 1 - Vascular checkup examinations: After collecting classic clinical parameters (weight, height, waist circumference), the in-depth vascular workup of each participant will include the following measurements: * Measurement of central arterial pressure, * Measurement of arterial stiffness, * Continuous blood pressure measurement (beat-to-beat), * Heart rate measurement, * 24-hour blood pressure measurement with QKD (holter). Part. 2 - Ophthalmological examinations: After dilating the pupil, a series of examinations will be conducted on the participant: * Auto-refractometry * Measurement of the axial length of the globe * Color retinophotography of the retina, * Adaptive Optics Exam * SS-OCT-A exam

Sponsors & Collaborators

  • University of Bordeaux

    collaborator OTHER

  • University Hospital, Bordeaux

    lead OTHER

Principal Investigators

  • Stéphanie DEBETTE, Pr · INSERM U1219 Bordeaux Population Health

Study Design

Allocation
NA
Purpose
PREVENTION
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-06-07
Primary Completion
2024-06-07
Completion
2024-06-07

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05305144 on ClinicalTrials.gov