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Quantiative MRI and Myelin-PET for the Assessment of Degenerative Cervical Myelopathy

NCT05242666 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2022-05-27

No results posted yet for this study

Summary

To use advanced imaging techniques, including MRI Brain and Spinal Cord, and MRI/PET Spinal Cord to provide an assessment of Degenerative Cervical Myelopathy to improve understanding of the pathophysiology and natural history of DCM.

Conditions

  • Cervical Spondylosis With Myelopathy
  • Degenerative Cervical Myelopathy

Interventions

DIAGNOSTIC_TEST

3T MR Imaging of the cervical spinal cord

Patients will undergo either Magnetic Resonance Imaging of the Spinal Cord

OTHER

Positron Emission Tomography using [11C]PIB

Patients will undergo combination MRI/PET using a \[11C\]PIB radiotracer

OTHER

3T MR Imaging of the Brain

3T MR Imaging of the Brain

OTHER

7T MR Imaging of the Spinal Cord

7T MR Imaging of the Spinal Cord

Sponsors & Collaborators

  • National Institute for Health Research, United Kingdom

    collaborator OTHER_GOV

  • Wolfson Brain Imaging Centre

    collaborator UNKNOWN

  • Cambridge University Hospitals NHS Foundation Trust

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-04-17
Primary Completion
2025-02-01
Completion
2025-02-01

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05242666 on ClinicalTrials.gov