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Taiwan Associated Genetic and Nongenetic Small Vessel Disease

NCT05473637 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 500

Last updated 2026-01-20

No results posted yet for this study

Summary

The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD genes, and patients will be divided into genetic or non-genetic groups accordingly. Their clinical features and outcome will be followed for at least 2 years.

Conditions

  • Cerebral Small Vessel Diseases
  • Cadasil
  • HTRA1-Related Autosomal Dominant Cerebral Angiopathy
  • COL4A1-Related Brain Small Vessel Disease With Haemorrhage
  • Fabry Disease
  • Magnetic Resonance Imaging
  • Next-generation Sequencing
  • Stroke

Interventions

DIAGNOSTIC_TEST

MRI

Patients will repeat study-protocol MRI at baseline (enrollment) and at least once in 1 year or 2 years follow-up (depends on availability).

Sponsors & Collaborators

  • National Taiwan University Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-01-01
Primary Completion
2026-12-31
Completion
2028-12-31

Countries

  • Taiwan

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05473637 on ClinicalTrials.gov