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Brain Imaging in Cerebral Venous Outflow Disturbance

NCT05820165 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2023-04-19

No results posted yet for this study

Summary

Cerebral venous outflow disturbance can lead to cerebral hemodynamic disturbances, altered cerebrospinal fluid dynamics, cerebral venous blood stasis, increased cerebral venous pressure and decreased cerebral perfusion, cerebral white matter sparing-like changes, and widening of retinal vessel diameter. These changes are associated with numerous neurological signs and symptoms. Therefore, understanding the brain structural and functional changes in patients with cerebral venous outflow disturbance is essential to provide specific imaging evaluation indicators and new diagnosis and treatment methods for patients with cerebral venous return disorders.

Conditions

  • Abnormal Cerebral Venous Sinus Morphology
  • Internal Jugular Vein Stenosis
  • Image

Interventions

RADIATION

high-resolution 3D-T1

Subjects undergo a high-resolution 3D-T1 imaging to obtain structural images

RADIATION

diffusion tensor imaging (DTI)

Subjects undergo a DTI imaging to obtain images of white matter lesions

RADIATION

resting-state functional magnetic resonance imaging (rs-fMRI)

Subjects undergo rs-fMRI to investigate the differences in intra-regional brain activity and inter-regional functional connectivity

RADIATION

arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI)

Subjects undergo arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) to clarify the difference of cerebral blood flow (CBF) perfusion in certain regions

RADIATION

susceptibility-weighted images (SWIs)

Subjects undergo susceptibility-weighted images (SWIs) to segment the vein network

Sponsors & Collaborators

  • Capital Medical University

    lead OTHER

Principal Investigators

  • Xunming Ji, MD.PhD · Xuanwu Hospital, Beijing

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-03-01
Primary Completion
2023-12-31
Completion
2024-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05820165 on ClinicalTrials.gov