Effects of HFNC on Moderate and Severe Respiratory Failure Patients

Summary

Respiratory failure is the danger for the patients admitted in ICU, mechanical ventilation could save a lot of patients' life, however, it prolongs patients' ICU stay and hospital stay. High flow nasal cannula (HFNC) has advantages of PEEP effects, reducing dead space, increasing EELV and improving comfort, and it has been used to treat respiratory failure patients. In recent study, HFNC could improve mortality of respiratory failure patients with P/F\<200mmHg in the subgroup. The investigators want to start a randomized controlled study to evaluate the effects of HFNC on the patients with respiratory failure.

Conditions

• Respiratory Failure

Interventions

DEVICE

HFNC

patients treated with high flow nasal cannula

DEVICE

NIV

patients treated with noninvasive ventilation

Sponsors & Collaborators

• First Affiliated Hospital of Suzhou Medical College

  collaborator OTHER

• Second Affiliated Hospital of Suzhou University

  collaborator OTHER

• Zhangjiagang First People's Hospital

  collaborator OTHER

• The Second Hospital of Nanjing Medical University

  collaborator OTHER

• Wuxi No. 4 People's Hospital

  collaborator OTHER

• Southeast University, China

  lead OTHER

Principal Investigators

• Chun Pan, Dr · Zhongda hospital, Southeast University, Jiangsu, China

• Fuxi Sun, Dr · Nanjing Medical University affiliated Second Hospital

• Wei Liu, Dr · Wuxi Hospital

• Jianfeng Xie, Dr · Suzhou Shili Hospital

• Songqiao Liu, Dr · Suzhou Sencond Hospital

• Ling Liu, Dr · Zhangjiagang Hospital

Study Design

Allocation

NA

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-01-31

Primary Completion

2016-12-31

Completion

2017-12-31