Molecular Transducers of Physical Activity Consortium (MoTrPAC) - Pediatric Protocol

Summary

The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity (PA). To achieve this aim, studies will be conducted in adults and separately in children and adolescents. The UC Irvine MoTrPAC Pediatric Clinical Center oversees two interrelated study phases in children and adolescents:

1. A cross-sectional phase in which molecular transducers (obtained from blood sampling) are measured in response to an acute exercise challenge (n = 320);
2. An intervention phase is conducted as a mechanistic randomized controlled trial (RCT). Participants are recruited from the cross-sectional study phase and randomized to endurance exercise (EE) training (n = 120) or no exercise Control (n = 50) for a period of approximately 12 weeks.

Conditions

• Physical Activity

Interventions

OTHER

EE Training

Participants randomized to EE training engage in three school-based or center-based (PERC) EE training sessions each week for approximately 12 weeks; each session lasting roughly 70 min with a 45-50 minutes of a stimulus phase and the remaining time being used to warm-up and cool down.

Sponsors & Collaborators

• National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

  collaborator NIH

• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  collaborator NIH

• Stanford University

  collaborator OTHER

• Broad Institute of MIT and Harvard

  collaborator OTHER

• Duke University

  collaborator OTHER

• Emory University

  collaborator OTHER

• Icahn School of Medicine at Mount Sinai

  collaborator OTHER

• Mayo Clinic

  collaborator OTHER

• Pacific Northwest National Laboratory

  collaborator FED

• University of Michigan

  collaborator OTHER

• Wake Forest University

  collaborator OTHER

• University of Vermont

  collaborator OTHER

• National Institutes of Health (NIH)

  collaborator NIH

• Wake Forest University Health Sciences

  lead OTHER

Principal Investigators

• Mike E Miller, PhD · Wake Forest University Health Sciences

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

10 Years

Max Age

17 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-11-22

Primary Completion

2025-05-31

Completion

2025-05-31

Countries

• United States

Study Locations