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Uric Acid Metabolism, Endothelial Function and Oxidative Stress in Vegans and Omnivores.

NCT03849677 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 103

Last updated 2020-07-01

No results posted yet for this study

Summary

50 vegans and 50 omnivores will be recruited at the Erasme Hospital, Brussels.

Hypothesis

* Relative induced-hyperuricemia by the vegan diet is not associated with impaired endothelial function if vitamin B12 and folic acid levels are normal.
* Quantification of xanthine oxidoreductase (XOR) isoforms varies according to the diet. Omnivores present more xanthine oxidase (XO) than vegans in which the xanthine dehydrogenase (XD) isoform is more prevalent.
* The vegan group has more favorable oxidant, metabolic and inflammatory profiles than the omnivore group.

Conditions

  • Healthy
  • Diet Modification

Interventions

OTHER

Endothelial function and inflammation

Analysis of endothelial function, oxidative stress

Sponsors & Collaborators

  • Fonds National de la Recherche Scientifique

    collaborator OTHER

  • Fonds Erasme

    collaborator UNKNOWN

  • Fonds pour la chirurgie cardiaque

    collaborator UNKNOWN

  • Erasme University Hospital

    lead OTHER

Eligibility

Min Age
20 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-03-10
Primary Completion
2020-03-30
Completion
2020-06-20

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03849677 on ClinicalTrials.gov