Determination of a Dose-dependent Effect of GOS on Iron Absorption, and Addition of Vitamin C

Summary

Iron deficiency is still the most common and widespread nutritional disorder in the world according to WHO.

In a recent iron absorption study in adult women with low iron stores in our lab (publication under review), we found that 15 g of GOS given with an iron supplement in the form of iron fumarate acutely increased iron absorption when given with water and a bread based meal. The dose of 15 g of GOS was tolerated well by the participants. As a follow up to the study mentioned above, we want to investigate: 1) if acute iron absorption is affected by lower doses of GOS; 2) whether this acute effect occurs for other commonly used iron compounds as well, such as iron sulphate and iron phosphate; and 3) if there are potential interactions on absorption with other enhancers of iron absorption, such as vitamin c.

Conditions

• Iron-deficiency

Interventions

DIETARY_SUPPLEMENT

ferrous fumarate

nutritional iron (14 mg) supplement in form of ferrous fumarate

DIETARY_SUPPLEMENT

ferrous sulphate

nutritional iron (14 mg) supplement in form of ferrous sulphate

DIETARY_SUPPLEMENT

ferric pyrophosphate

nutritional iron (14 mg) supplement in form of ferric pyrophosphate

DIETARY_SUPPLEMENT

ferrous fumarate + 3.5 g GOS

nutritional iron (14 mg) supplement in form of ferrous fumarate with addition of prebiotics (3.5 g GOS)

DIETARY_SUPPLEMENT

ferrous fumarate + 7 g GOS

nutritional iron (14 mg) supplement in form of ferrous fumarate with addition of prebiotics (7 g GOS)

DIETARY_SUPPLEMENT

ferrous sulphate + 15 g GOS

nutritional iron (14 mg) supplement in form of ferrous sulphate with addition of prebiotics (15 g GOS)

DIETARY_SUPPLEMENT

ferrous fumarate + Vitamin C

nutritional iron (14 mg) supplement in form of ferrous fumarate with addition of Vitamin C

DIETARY_SUPPLEMENT

ferric pyrophosphate + 15 g GOS

nutritional iron (14 mg) supplement in form of ferric pyrophosphate with addition of prebiotics (15 g GOS)

DIETARY_SUPPLEMENT

ferrous fumarate + 7 g GOS + Vitamin C

nutritional iron (14 mg) supplement in form of ferrous fumarate with addition of prebiotics (7 g GOS) and Vitamin C

Sponsors & Collaborators

• Burgerstein Vitamine

  collaborator INDUSTRY

• Isabelle Herter-Aeberli

  lead OTHER

Principal Investigators

• Isabelle Herter-Aeberli, Dr. · University of Zurich

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

45 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-04-01

Primary Completion

2019-06-11

Completion

2019-06-11

Countries

• Switzerland

Study Locations