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Effect of Prebiotics on Iron Absorption in Women With Low Iron Stores

NCT03325270 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 46

Last updated 2019-01-16

No results posted yet for this study

Summary

Rationale:

According to the WHO, iron deficiency is still the most common and widespread nutritional disorder in the world. Current iron supplements have limitations in terms of bioavailability and tolerability. Prebiotic fibers, such as galacto-oligosaccharides (GOS), selectively enhance growth of beneficial colonic bacteria. Prebiotics in general enhance the production of short-chain fatty acids (SCFAs) and thereby decrease luminal pH. Through the reduction in colonic pH, prebiotics can enhance absorption of minerals such as calcium and magnesium and they have been proposed to potentially improve iron absorption as well.

The primary objective of this study is to investigate the effect of an addition of GOS to an iron supplement on iron absorption in iron deplete, healthy, normal weight women.

Conditions

  • Iron-deficiency

Interventions

DIETARY_SUPPLEMENT

labeled ferrous fumarate

labeled iron as Ferrous Fumarate

DIETARY_SUPPLEMENT

labeled ferrous fumarate + prebiotics

labeled iron as Ferrous Fumarate + galacto-oligosaccharides

DIETARY_SUPPLEMENT

labeled ferrous sulfate + prebiotics

labeled iron as Ferrous Sulfate + galacto-oligosaccharides

Sponsors & Collaborators

  • Burgerstein Vitamine

    collaborator INDUSTRY

  • Swiss Federal Institute of Technology

    lead OTHER

Principal Investigators

  • Michael Zimmermann, Prof. Dr. · University of Zurich

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-01-10
Primary Completion
2018-04-28
Completion
2018-04-28

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03325270 on ClinicalTrials.gov