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Iron Bioavailability From Encapsulated Ferrous Sulphate

NCT02353325 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2017-06-12

No results posted yet for this study

Summary

Salt is one of the very few regularly purchased food item in all socioeconomic classes including poor remote areas with subsistence farming. Therefore, it is a promising vehicle for fortification with micronutrients, such as iodine, iron, vitamin A, to alleviate the burden of micronutrient deficiencies. However, ensuring the bioavailability of iron and the sensory quality in fortified salt is difficult. Water-soluble iron compounds, such as ferrous sulphate FeSO4, are the most bioavailable, but they react with moisture and impurities in salt, and cause unacceptable changes in colour. Encapsulation can reduce iron-mediated colour change in fortified salt without significantly compromise bioavailability. In the present project we aim to investigate the iron bioavailability from salt fortified with FeSO4 using a new encapsulation type based on hyaluronic acid (HA) and a polymer from the eudragit family (EPO).

Conditions

Interventions

DIETARY_SUPPLEMENT

non-encapsulated FeSO4

DIETARY_SUPPLEMENT

encapsulated FeSO4, before cooking

DIETARY_SUPPLEMENT

encapsulated FeSO4, after cooking

DIETARY_SUPPLEMENT

non-encapsulated FeSO4 + ascorbic acid

DIETARY_SUPPLEMENT

encapsulated FeSO4 + ascorbic acid, before cooking

DIETARY_SUPPLEMENT

encapsulated FeSO4 + ascorbic acid, after cooking

Sponsors & Collaborators

  • Swiss Federal Institute of Technology

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-03-31
Primary Completion
2016-05-31
Completion
2016-06-30

Countries

  • Switzerland

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02353325 on ClinicalTrials.gov