Xenotransplantation of Primary Cancer Samples in Zebrafish Embryos

Summary

The study consists in a co-clinical trial by using zebrafish embryos. Specifically, an observational prospective clinical trial on patients operated of epato-biliar-pancreatic cancers and gastro-intestinal cancers undergoing a chemotherapy treatment will be run concurrently to an animal trial on zebrafish embryos xenotransplanted with patient cancer cells in order to demonstrate that zebrafish model is able to predict the therapeutic regimen with the best efficacy for each patient.

Conditions

• Liver Cancer
• Pancreatic Cancer
• Gastric Cancer
• Esophageal Cancer
• Colo-rectal Cancer
• Gall Bladder Cancer
• Biliary Tract Cancer

Interventions

DRUG

Fluorouracil

The enrolled patients after the surgical operation will undergo to the adjuvant chemotherapy treatment

DRUG

Lederfolin

The enrolled patients after the surgical operation will undergo to the adjuvant chemotherapy treatment

DRUG

Oxaliplatin

The enrolled patients after the surgical operation will undergo to the adjuvant chemotherapy treatment

DRUG

Irinotecan

The enrolled patients after the surgical operation will undergo to the adjuvant chemotherapy treatment

DRUG

Docetaxel

The enrolled patients after the surgical operation will undergo to the adjuvant chemotherapy treatment

DRUG

Cisplatin

The enrolled patients after the surgical operation will undergo to the adjuvant chemotherapy treatment

DRUG

Epirubicin

The enrolled patients after the surgical operation will undergo to the adjuvant chemotherapy treatment

DRUG

Gemcitabine

The enrolled patients after the surgical operation will undergo to the adjuvant chemotherapy treatment

DRUG

Nab paclitaxel

The enrolled patients after the surgical operation will undergo to the adjuvant chemotherapy treatment

Sponsors & Collaborators

• Azienda Ospedaliero, Universitaria Pisana

  collaborator OTHER

• University of Pisa

  lead OTHER

Principal Investigators

• Luca Morelli, Prof · University of Pisa

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2018-06-01

Primary Completion

2021-05-31

Completion

2022-05-31

FDA Drug

Yes

Countries

• Italy

Study Locations