Liver cancer is a malignant disease in which cancer cells form in liver tissue, with hepatocellular carcinoma being the predominant subtype of primary liver cancer. It is a major global cancer burden and often associated with chronic liver disease risk factors.
Recent studies have uncovered new cancer therapeutic targets and strategies, including self-assembling antibody-drug conjugates, a dual-action metabolic drug, and a BRAF protein structure. Research also advanced on dendritic cell vaccines, the origins of a rare childhood leukemia, and cancer cachexia treatment.
Medivir AB completed an oversubscribed share issue to fund MIV-711 for Legg-Calvé-Perthes disease. MIV-711 is advancing to phase II for osteogenesis imperfecta with FDA orphan drug status. Cash runway extends to 2028 and other pipeline programs are progressing.
Preclinical studies reveal that fructose promotes metastasis in ovarian cancer by reducing cell adhesion, while brigatinib enhances PARP inhibitor efficacy by blocking an early adaptive resistance mechanism. The findings suggest dietary modifications and repurposing a lung cancer drug could improve outcomes for high-grade serous ovarian cancer patients.
New studies reveal how cancer cells survive chemotherapy: fructose promotes ovarian cancer spread, platinum-treated 'zombie cells' release TGFβ in lung and ovarian cancers, and mitochondrial metabolism drives 5FU resistance in colorectal cancer. The findings point to potential combination therapy targets.
A study finds end-to-side anastomosis for Crohn’s disease may reduce endoscopic recurrence, while global data show early-onset colorectal cancer has the highest GI cancer burden in young adults, with rising incidence. Both studies highlight evolving challenges and treatment options in gastroenterology.
In the Philippines, an estimated 7.3 million adults live with chronic hepatitis B, far above regional averages. Experts warn that complex treatment guidelines may hinder front-line clinicians from initiating care, while Thailand’s success with vaccination shows a path to elimination. Expanding screening and simplifying treatment are critical steps.
UNM Comprehensive Cancer Center installs MRI-LINAC, enabling real-time tumor tracking and adaptive radiation therapy. The system has treated 10 patients and improves precision, reducing damage to healthy tissue.
New research links coffee to lower liver disease risk and sugary beverages to higher liver cancer risk. Two studies appear in Clinical Gastroenterology and Hepatology and JAMA Network Open.
Research highlights ferroptosis for overcoming drug resistance in digestive cancers. A study of Fuzheng Pill identified 236 components and showed it promotes apoptosis via the mitochondrial pathway.
Researchers report advances in RNA-based gene therapy: an FDA-approved small molecule modulates RNA splicing, protein-coated nanoparticles enable safer delivery, and a microRNA platform targets glioblastoma.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07763301 |
YMN-136 Vaccine for Patients With Advanced Hepatobiliary and Pancreatic Malignancies |
RECRUITING | PHASE1 |
| NCT07741903 |
Development of a Risk Prediction Model for Immune-Targeted Therapy-Related Diarrhea in Patients With Hepatocellular Carcinoma Based on TCM Constitutional Types: A Prospective Cohort Study |
NOT_YET_RECRUITING | |
| NCT07717437 |
DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection. |
RECRUITING | |
| NCT07690683 |
Patients With Hepatocellular Carcinoma (HCC) |
NOT_YET_RECRUITING | NA |
| NCT07685535 |
HAIC + DEB-TACE + Toripalimab + Lenvatinib for Unresectable Intrahepatic Cholangiocarcinoma |
NOT_YET_RECRUITING | PHASE2 |
| NCT07676383 |
Precision Navigation to Improve Community Cancer Screening Participation |
NOT_YET_RECRUITING | NA |
| NCT07658586 |
AI Multimodal Model for Liver Cancer Diagnosis and Prognosis |
ACTIVE_NOT_RECRUITING | |
| NCT07658313 |
Digitally Supported Prehabilitation Before Major Visceral Cancer Surgery |
NOT_YET_RECRUITING | NA |
| NCT07653594 |
TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE) |
NOT_YET_RECRUITING | NA |
| NCT07645209 |
A Real-world Study of Immunotherapy Combination Regimens for Treating Liver Cancer in Cold Regions |
ACTIVE_NOT_RECRUITING |
