MedTrace Logo

PheWAS of a Polygenic Predictor of Thyroid Function

NCT03597659 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 37154

Last updated 2019-09-26

No results posted yet for this study

Summary

Performing a phenome-wide association study (PheWAS) identifying clinical diagnoses associated with a polygenic predictor of Thyroid stimulating hormone (TSH) levels identified by a previously published genome-wide association study (GWAS). PheWAS will be applied in an electronic-health-record (EHR) cohort including North American (n: 37,154) and European participants using 1,318 phenotypes.

Conditions

  • Thyroid
  • Genetic Predisposition to Disease

Interventions

GENETIC

phenome-wide association study (PheWAS)

Phenome-wide association study (PheWAS) identifying clinical diagnoses associated with a polygenic predictor of TSH levels identified by a previously published genome-wide association study (GWAS) which included North American and European participants. A phenome-wide scanning of 1,318 phenotypes will be performed, using a cohort of 37,154 North American individuals of European ancestry with electronic-health-record (EHR) data.

Sponsors & Collaborators

  • Vanderbilt University Medical Center

    collaborator OTHER

  • Groupe Hospitalier Pitie-Salpetriere

    lead OTHER

Eligibility

Min Age
28 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-09-01
Primary Completion
2018-07-01
Completion
2018-07-01

Countries

  • France

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03597659 on ClinicalTrials.gov