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Blood Vessel Study

NCT01524549 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 178

Last updated 2026-04-08

No results posted yet for this study

Summary

Background:

\- The endothelium is the inner lining of blood vessels. The cells in this lining help regulate blood flow and immune system function. Problems with endothelial cells can contribute to heart disease, high blood pressure, and diabetes. Certain genes or parts of genes may be related to problems with endothelial function. Researchers want to study healthy adults who have genes that may affect their endothelial function. More information on these genes may provide more information on genetic risk for certain diseases.

Objectives:

\- To study healthy adults who have genetic markers related to endothelial cell problems.

Eligibility:

* Healthy volunteers between 18 and 65 years of age.
* Current participants of the Environmental Polymorphisms Registry and have certain genes related to endothelial cell problems.

Design:

* Participants will have a single study visit to collect information and samples.
* Participants will be screened with a physical exam and medical history. Blood and urine samples will be collected.
* Participants will have an ultrasound of the artery in the arm and will be given a short-acting medication called nitroglycerin to study blood flow and blood pressure.

Conditions

Sponsors & Collaborators

  • National Institute of Environmental Health Sciences (NIEHS)

    lead NIH

Principal Investigators

  • Darryl C Zeldin, M.D. · National Institute of Environmental Health Sciences (NIEHS)

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-03-01

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01524549 on ClinicalTrials.gov