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Development of a Risk Prediction Algorithm Through the Investigation of Genetic Risk Factors and the Complexity of Coronary Artery Disease to Estimate Future Risk of Cardiovascular Events: Angiographic (SYNTAX Score), Clinical and Pharmacogenetic Analysis.

NCT03150680 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 1080

Last updated 2017-09-07

No results posted yet for this study

Summary

The purpose of the research project is to investigate the potential association of 207 genetic polymorphisms with the complexity and the severity of coronary artery disease (SYNTAX score), along with the patients' response to clopidogrel and statin therapy. The aim of the study is to combine genetic, pharmacogenetic, clinical and laboratory data in order to create an algorithm (GEnetic Syntax Score-GESS) that will enable an individualized therapeutic patient approach.

Conditions

Interventions

GENETIC

SNPs associated with CAD, SNPs associated with pharmacological response to clopidogrel and statins

Genotyping will be carried out by Next-Generation Sequencing (NGS)

Sponsors & Collaborators

  • LABNET IAE - Private Reference Diagnostic Laboratory

    collaborator UNKNOWN

  • AHEPA University Hospital

    lead OTHER

Principal Investigators

  • Georgios Sianos, MD PhD FESC · AHEPA University Hospital

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-09-01
Primary Completion
2020-02-29
Completion
2020-09-30

Countries

  • Greece

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03150680 on ClinicalTrials.gov