FAMILY INHERITANCE, GENE-GENE AND GENE-ENVIRONMENT INTERACTIONS IN THE FIELD OF CARDIOVASCULAR AND RENAL DISEASES. Fifth Visit of the STANISLAS Cohort

Summary

The Stanislas Cohort is a monocentric familial longitudinal cohort originally comprised of 1006 families consisting of two parents and at least two biological children and deemed healthy, recruited in 1993-1995 at the Centre for Preventive Medicine of Nancy. This cohort was established with the primary objective of investigating gene-gene and gene-environment interactions in the field of cardiovascular diseases. The 5th visit of the STANISLAS Cohort will allow a better evaluation of the cardiovascular ageing of the population and the transition toward cardiovascular or renal diseases in relation with their genetic profile and environment.

Conditions

• Cardiovascular Diseases
• Cohort Studies
• Genotype
• Risk Factors
• Nutrition

Interventions

BEHAVIORAL

Dietary intake

Food frequency questionnaires, ''Dutch eating behaviour questionnaire'' and dietary supplement questionnaire

OTHER

Anthropometric parameters

Measurement of height, weight, abdominal circumference, hip circumference, arm circumference

OTHER

Hemodynamic parameters

Systolic pressure index measurement

OTHER

Hemodynamic parameters

Heart rate measurements, blood pressure measurements, orthostatic BP measurements

OTHER

Hemodynamic parameters

Blood pressure measurements by "unattended BP" monitor over 5 min

OTHER

Hemodynamic parameters

Electrocardiogram

BIOLOGICAL

Blood and urine samples

Blood and urine samples

GENETIC

Blood samples

Blood samples

OTHER

Cardiovascular assessment

Echocardiography, Lung ultrasound, pulse wave velocity, carotid stiffness and thickness, Central and peripheral blood pressure, carotid pulse pressure, abdominal aorta ultrasound, jugular vein ultrasound, liver elastography (Optional).

BEHAVIORAL

Assessment of compliance with antihypertensive treatments for treated participants

EVALOBS scale and compliance questionnaire

OTHER

Ambulatory 24 hours measurment of blood pressure

For the first 100 patients willing to participate

BIOLOGICAL

24 hours urinary collection

For the first 100 patients willing to participate. For biobank constitution and measurement of microalbuminuria, creatininuria, osmolarity, natriuresis, kaliuresis, urea, proteinuria and urine dipstick

OTHER

General questionnaires

Collection of socio-demographic data such as age, level of education, profession, household income, smoking status, physical activity, perception of health, prematurity, height and weight at birth, family and personal history especially cardiovascular (history of stroke, myocardial infarction, heart failure, current pathologies, drugs, tobacco...)

OTHER

Women specific questionnaire

Women specific questionnaire

BEHAVIORAL

Women specific questionnaire

Women specific questionnaire

DIAGNOSTIC_TEST

NYHA dyspnea questionnaire

Determination of NYHA class.

BEHAVIORAL

Anxiety questionnaire

Assessment of anxiety

BEHAVIORAL

Epworth Sleepiness Scale

sleep quality assessment

OTHER

A questionnaire on the "perception of the management of cardiovascular risk factors"

Patient's evaluation of cardiovascular risk factors by the health system

BEHAVIORAL

A questionnaire on eating behaviors

Assessment of eating behaviors

BEHAVIORAL

A questionnaire on eating habits to determine consumer profiles

Assessement of eating habit to create a consumer profile

DIETARY_SUPPLEMENT

A questionnaire on food supplements use

Evaluation od food supplements intake

OTHER

SARS-CoV-2 Infection Questionnaire

SARS-CoV-2 Infection Questionnaire

OTHER

Instantaneous expired air analysis

Carbon monoxyde analysis in expired air

BIOLOGICAL

Capillary sampling

Capillary sampling for pollutant analysis (Optional)

Sponsors & Collaborators

• Central Hospital, Nancy, France

  lead OTHER

Principal Investigators

• Nicolas Girerd, MD, PhD · Centre d'Investigation Clinique 1433 module Plurithématique - CHRU Nancy

Study Design

Allocation

NA

Purpose

OTHER

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-07-13

Primary Completion

2027-07-13

Completion

2027-07-13

Countries

• France

Study Locations