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Does Consuming Modified Plant Seed Oil Containing Fish Oil Fatty Acids Act in the Same Way as Consuming Fish Oil?

NCT03477045 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 31

Last updated 2022-06-15

No results posted yet for this study

Summary

Fish oil and oily fish contain omega 3 long chain polyunsaturated fatty acids known to be beneficial to health. Many people consume little, despite UK government recommendations to eat at least one portion of oily fish per week. Furthermore, despite modest consumption, fish stocks are declining due to over fishing. Therefore, there is a need for an alternative, sustainable and cost efficiently produced dietary source. A seed oil source of these fish oil-type fatty acids has been achieved by adding genes from other plant sources to the oil seed plant Camelina sativa. Camelina sativa, related to mustard and cabbage, has provided seed oil for human consumption for thousands of years. It was the most important oil seed plant in Europe until the 1900's. This research is being done to see if consuming fish oil-type fatty acids in Camelina seed oil allows the body to take up and use the fish oil fatty acids in the same way as it does from fish oil.

Conditions

  • Healthy

Interventions

DIETARY_SUPPLEMENT

Single dose fish oil

Fish oil consumed within a single high fat test meal

DIETARY_SUPPLEMENT

Repeated dose fish oil

Fish oil consumed daily for 8 weeks

DIETARY_SUPPLEMENT

single dose Camelina seed oil

camelina seed oil consumed within a single high fat test meal

DIETARY_SUPPLEMENT

repeated dose camelina seed oil

camelina seed oil consumed daily for 8 weeks

Sponsors & Collaborators

  • University of Southampton

    lead OTHER

Principal Investigators

  • Graham C Burdge, PhD · University of Southampton

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-06-09
Primary Completion
2019-11-04
Completion
2019-11-04

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03477045 on ClinicalTrials.gov