What is the Best Sperm Source and Way of Sperm Selection in Cases With Abnormal sORP Levels on the Day of ICSI?

Summary

Does the level of statistic oxidation reduction potential (sORP) affects the choice of sperm source or sperm selection method used during ICSI.

Conditions

• Oxidative Stress

Interventions

DEVICE

PICSI

Semen processing is done by double layer density gradient method followed by adding Sperm to the dot of hyaluronan on the PICSI dish, within minutes the bound sperm are attached by their acrosome to the surface of the dot. (Selecting an individual bound sperm with enhanced genetic and developmental integrity ensures that the sperm selected is the optimal sperm from the sample for oocyte injection.

PROCEDURE

TESA

Patients will undergo TESA which is performed by sticking a needle in the testis and aspirating fluid and tissue with negative pressure then examine the sample for presence of motile sperms followed by sample processing and oocyte injection.

Sponsors & Collaborators

• The Cleveland Clinic

  collaborator OTHER

• University of the Western Cape

  collaborator OTHER

• Ganin Fertility Center

  lead OTHER

Principal Investigators

• Eman Hasanen, BSc · Ganin Fertility Center, Cairo, Egypt

• Hosam Zaki, MSc, FRCOG · Ganin Fertility Center, Cairo, Egypt

• Khaled Elqusi, BSc · Ganin Fertility Center, Cairo, Egypt

• Ashok Agarwal, Ph.D · American Center of reproductive medicine, Cleveland Clinic, Ohio, USA

• Ralph Henkel, PhD · University of the Western Cape

• Hanaa Elkhedr, ABB( ELD) · Ganin Fertility Center, Cairo, Egypt

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

MALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-11-20

Primary Completion

2019-12-30

Completion

2019-12-30

Countries

• Egypt

Study Locations