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The Role of GABA-mediated Inhibition in Multisensory Temporal Processing & Postural Control in Older Adults

NCT03328455 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2026-05-01

No results posted yet for this study

Summary

In recent years evidence has accumulated on the association between age-related decline in multisensory temporal processing and postural control. This proposed project aims at examining GABA-mediated inhibition as the potential mechanism behind this link. Our overarching hypothesis is that changes in the excitatory-inhibitory balance with a reduction of GABAergic inhibition is a common mechanism underlying age-related multisensory and postural deficits potentially mediated by age-related reduction in network segregation. To test this hypothesis, we will assess the relationship between age-related multisensory/postural deficits and age-related reduction in GABA concentration in related brain areas and probe the role of GABA-mediated inhibition using cognitive training that specifically targets inhibitory functions. Our multimodal approach is innovative, and findings from this study has the potential to lead to the development of safe and effective rehabilitation protocols for older adults with impaired multisensory temporal integration and postural control.

Conditions

  • Healthy Aging

Interventions

BEHAVIORAL

Inhibitory control training

Cognitive training is inhibitory task-related.

BEHAVIORAL

Knowledge-based training

Training is not inhibitory task-related.

Sponsors & Collaborators

  • University of Nevada, Reno

    lead OTHER

Principal Investigators

  • Fang Jiang, Ph.D · University of Nevada, Reno

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2027-12-01
Primary Completion
2030-11-30
Completion
2031-11-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03328455 on ClinicalTrials.gov