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TransplantLines Insulin Resistance and Inflammation Biobank and Cohort Study

NCT03272854 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 606

Last updated 2017-09-06

No results posted yet for this study

Summary

Short-term (1-year) results of renal transplantation are now excellent (over 95%). Long-term (10-year and longer) results are, however, still disappointing. Where most research has focused on immunosuppression and infections, the investigators hypothesize that in renal transplant recipient, amongst others overweight, obesity, chronic use of immunosuppressive drugs and impaired renal function contribute to insulin resistance and chronic low-grade inflammation, which pose the renal transplant recipients at increased risk for cardiovascular disease, decline of function of the transplanted kidney and other complications, including post-transplant diabetes. This study is a biobank and cohort study which investigates this hypothesis.

Conditions

  • Death
  • Graft Failure
  • Death, Cardiac
  • Diabetes

Interventions

OTHER

No intervention performed, the study is observational

Sponsors & Collaborators

  • University Medical Center Groningen

    lead OTHER

Principal Investigators

  • Stephan JL Bakker, MD, PhD · University Medical Center Groningen

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2001-08-31
Primary Completion
2003-07-31
Completion
2031-08-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03272854 on ClinicalTrials.gov