Biomarkers of Kidney Function in Transplant Medicine

Summary

Biomarkers of kidney function in transplant medicine is an international, multicentre, observational, non-interventional study.

The project is aimed at monitoring biomarkers of acute kidney dysfunction in deceased organ donors, living organ donors, and organ recipients.

Conditions

• Acute Kidney Injury

Interventions

DIAGNOSTIC_TEST

Laboratory values - baseline

Baseline laboratory values will be obtained

OTHER

Medical information 12 hours before organ harvesting

* average hourly diuresis * hypotension MAP\<65 Torr longer than 30 minutes (YES/NO) * Furosemide administration (YES/NO) * Mannitol administration (YES/NO) * administration of anti-diuretic hormone (YES/NO) * administration of vasopressors (YES/NO) * polyuria \>3ml/kg/h (YES/NO) * nephrotoxic agents during hospitalization (YES/NO)

DIAGNOSTIC_TEST

Laboratory values - 12 hours after reperfusion

Laboratory values will be obtained 12 hours after reperfusion

DIAGNOSTIC_TEST

Laboratory values - 48 hours after reperfusion

Laboratory values will be obtained 48 hours after reperfusion

DIAGNOSTIC_TEST

Laboratory values - 7 days after reperfusion

Laboratory values will be obtained 7 days after reperfusion

DIAGNOSTIC_TEST

Laboratory values - 90 days after reperfusion

Laboratory values will be obtained 90 days after reperfusion

OTHER

Medical information during organ harvesting/transplantation

Medical information during organ harvesting/transplantation * hypotension MAP 65 Torr \> 5 minutes (YES/NO) * vasopressor support (YES/NO, duration in minutes)

PROCEDURE

Organ harvesting

Organ harvesting for transplant

PROCEDURE

Organ transplantation

Transplantation of the harvested organ

Sponsors & Collaborators

• University Hospital Ostrava

  lead OTHER

Principal Investigators

• Peter Sklienka, MD, Ph.D. · University Hospital Ostrava

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-01-01

Primary Completion

2025-12-31

Completion

2026-03-31

Countries

• Czechia

Study Locations