Prospective Cohort Study of 4,837 Post-myocardial Infarction Patients (Alpha Omega Cohort)

Summary

The Alpha Omega Cohort is a prospective study of 4,837 state-of-the-art drug-treated Dutch patients aged 60-80 years who had a clinically diagnosed myocardial infarction up to 10 years before enrolment. During the first 40 months of follow-up, patients took part in an experimental study of low doses n-3 fatty acids (Alpha Omega Trial, ClinicalTrials.gov NCT00127452). At baseline (2002-2006), data on medical history, medication use, diet, lifestyle and other factors were collected by means of questionnaires. Patients were physically examined by trained research nurses and blood samples were obtained. Follow-up for vital status and cause-specific mortality is ongoing. The trial was approved by a central medical ethics committee (Haga Hospital, The Hague, The Netherlands) and all patients provided written informed consent.

Conditions

• Cardiovascular Diseases
• Mortality
• Type 2 Diabetes Mellitus
• Cognitive Decline
• Mental Well-being
• Kidney Function

Interventions

BEHAVIORAL

Dietary intake

Intake of nutrients, foods, food groups, beverages; dietary patterns.

BEHAVIORAL

Lifestyle factors

Physical activity; smoking; alcohol use; educational level.

BIOLOGICAL

Blood biomarkers

Biomarkers of dietary intake (e.g. fatty acids); biomarkers of disease.

BIOLOGICAL

Health

Current health status; medical history; medication use; self-rated health; risk factors for disease (e.g. body mass index, blood pressure, blood lipids, glucose)

GENETIC

DNA

SNPs (GWAS)

BIOLOGICAL

Mental well-being

Cognitive function; dispositional optimism; depression.

Sponsors & Collaborators

• Wageningen University

  lead OTHER

Principal Investigators

• Johanna M Geleijnse, PhD · Wageningen University, Division of Human Nutrition

Eligibility

Min Age

60 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2002-04-30

Primary Completion

2040-01-31

Completion

2040-01-31

Countries

• Netherlands

Study Locations